Production of Ciprofloxacin Hydrochloride (CIPRO) - Active Pharma Ingredient. Investment Opportunities in Pharmaceutical Industry.
Ciprofloxacin is an antibiotic. It belongs to a group of antibiotics called fluoroquinolone. Cipro (ciprofloxacin) is a brand-name prescription antibiotic medication. It’s used to treat infections caused by bacteria. Ciprofloxacin Hydrochloride is the hydrochloride salt form of ciprofloxacin, a fluoroquinolone related to nalidixic acid with antibacterial activity. Ciprofloxacin hydrochloride exerts its bactericidal effect by interfering with the bacterial DNA gyrase, thereby inhibiting the DNA synthesis and preventing bacterial cell growth.
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Uses and Applications
Ciprofloxacin is used to treat a number of infections including: infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, chancroid, among others.
CIPRO is indicated in adult patients for treatment of skin and skin structure infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Proteus vulgaris, Providencia stuartii, Morganella morganii, Citrobacter freundii, Pseudomonas aeruginosa, methicillin susceptible Staphylococcus aureus, methicillin-susceptible Staphylococcus epidermis’s, or Streptococcus pyogenic.
CIPRO is indicated in adult patients for treatment of typhoid fever (enteric fever) caused by Salmonella typhi. The efficacy of ciprofloxacin in the eradication of the chronic typhoid carrier state has not been demonstrated.
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Ciprofloxacin is a second generation fluoroquinolone antibiotic that is widely used in the therapy of mild-to-moderate urinary and respiratory tract infections caused by susceptible organisms. Ciprofloxacin has been linked to rare but convincing instances of liver injury that can be severe and even fatal.
Ciprofloxacin is given to treat a bacterial infection. It is useful for treating infections such as chest infections, urine infections, prostatitis, and infections of the digestive system, bone and joint infections, and some sexually transmitted infections. It works by killing the bacteria which are the cause of the infection.
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Application
v Urogenital Infections
v Respiratory Tract Infections
v Gastrointestinal Infections
v Typhoid
v Bone and Joint Infections
v Skin and Soft Tissue Infections
v Sepsis and Other Systemic Infections
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Government Initiatives
• Some of the initiatives taken by the Government to promote the pharmaceutical sector in India are as follows:
• India plans to set up a nearly Rs 1 lakh crore (US$ 1.3 billion) fund to provide boost to companies to manufacture pharmaceutical ingredients domestically by 2023.
• In November 2019, the Cabinet approved extension/renewal of extant Pharmaceuticals Purchase Policy (PPP) with the same terms and conditions while adding one additional product namely, Alcoholic Hand Disinfectant (AHD) to the existing list of 103 medicines till the final closure/strategic disinvestment of Pharma CPSUs.
• Under Budget 2020-21, Rs 65,012 crore (US$ 9.30 billion) has been allocated to the Ministry of Health and Family Welfare is. The Government has allocated Rs 34,115 crore (US$ 4.88 billion) towards the National Health Mission under which rural and urban people will get benefited.
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• Rs 6,400 crore (US$ 915.72 million) has been allocated to health insurance scheme Ayushman Bharat – Pradhan Mantri Jan Arogya Yojana (AB-PMJAY).
• As per Economic Survey 2019-20, Government expenditure (as a percentage of GDP) increased to 1.6 per cent in FY20 from 1.2 per cent in FY15 on health.
• The National Health Protection Scheme is the largest Government funded healthcare programme in the world, which is expected to benefit 100 million poor families in the country by providing a cover of up to Rs 5 lakh (US$ 7,723.2) per family per year for secondary and tertiary care hospitalization. The programme was announced in Union Budget 2018-19.
• The Government of India is planning to set up an electronic platform to regulate online pharmacies under a new policy to stop any misuse due to easy availability.
• Government of India unveiled 'Pharma Vision 2020' to make India a global leader in end-to-end drug manufacture. Approval time for new facilities has been reduced to boost investment.
• India has imposed a provisional anti-dumping duty on imports of Ciprofloxacin Hydrochloride from China on the grounds that it was hurting domestic industry, following an investigation of the Directorate General of Trade Remedies (DGTR).
• The department of revenue issued a notification to the effect on September 2, imposing a duty ranging between $0.94 and $3.29 per kg coming from China.
• Ciprofloxacin Hydrochloride is used to treat different types of bacterial infections and certain types of diarrhea. The DGTR had initiated the investigation in January this year.
Related Project:- Ciprofloxacin Hydrochloride
Market Outlook
The Indian pharmaceutical industry is the fourth largest in the world in terms of volume of output and thirteenth in domestic demand. However, the Indian industry, valued at USD 17 bn in represented just over 1% of the global pharmaceutical industry (USD 1700 bn) in value terms. The domestic market is estimated at Rs 680 bn.
The Global Ciprofloxacin Market is growing at a faster pace with substantial growth rates over the last few years and is estimated that the market will grow significantly in the forecasted period i.e. 2020 to 2027.
Ciprofloxacin is one of the broad spectrum antibiotics for the drug class quinolone antibiotic. The Ciprofloxacin antibiotic is primarily used to decrease the growth of drug resistant bacteriophage and sustain the efficacy of the antibiotic. Ciprofloxacin is only used in the bacterial infections, the drug doesn’t show any effect of viral infections. The higher absorption of the Ciprofloxacin in kidneys retain most of its concentration in the renal system. Which offers the advantage for the urinary tract infection treatment with Ciprofloxacin offering higher efficacy in treating urinary tract infection and renal infection. The use of Ciprofloxacin in various bacterial infection is anticipated to create lucrative growth opportunities for the Ciprofloxacin market. The overall annual cost of more than 2 billion is spent on hospitalization and office visits concerning urinary tract infection. The higher treatment seeking rate in renal infection is anticipated to propel the demand for Ciprofloxacin and subsequently increase the revenue share in Ciprofloxacin market.
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Export growth is driven by growing dependence on generics across the world acceptance of Indian generic drugs, aggressive expansion of Indian companies in international markets and entry of smaller companies into exports. By 2012 drugs worth USD 100 bn will lose patent protection.
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Key Players:-
Ø Aarti Drugs Ltd.
Ø Aurobindo Pharma Ltd.
Ø Cipla Ltd.
Ø Indoco Remedies Ltd.
Ø Kores (India) Ltd.
Ø Mylan Pharmaceuticals Pvt. Ltd.
Ø Neuland Laboratories Ltd.
Ø S S Organics Ltd
Ø Smruthi Organics Ltd.
Ø Sreepathi Pharmaceuticals Ltd.
Ø Sterling Basic Organics Ltd.
Ø Sun Pharma Laboratories Ltd.
Ø Sun Pharma Medisales Pvt. Ltd.
Ø Wockhardt Ltd.
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